Figure 1. Measurement of extracellular 5-HT in ileal tissues treated with E. coli Nissle 1917 and MG1655. Ileal tissue samples and E. coli cultures were co-incubated for 1 h at 37 °C, 5% CO 2 The aim of the present study was to examine the effect of rifaximin and/or Mutaflor ( Escherichia coli Nissle 1917, EcN) administration on the healing of acetic acid-induced colitis. Methods . Colitis was induced in male Wistar rats by rectal enema with 3.5% acetic acid solution. Rifaximin (50 mg/kg/dose) and/or Mutaflor (10 9 CFU/dose) were As a bacterial isolate from the pre-antibiotic era, E. coli strain Nissle 1917 (Mutaflor) is sensitive to all antibiotics which are predominately directed against Gram-negative bacteria, e. g. coli bacteria. A certain loss of ­Mutaflor-efficacy must be taken into account. Nevertheless, a protective ­Mutaflor-therapy should be initiated in Upon oral supplementation, this strain was protected from diarrhea and this strain was named as E. coli Nissle 1917(EcN) from the year after its use . Commercially, this strain is known as Mutaflor. EcN is the most commonly used gram-negative probiotic . Escherichia coli Nissle 1917 (Mutaflor) is one of the most investigated probiotic bacteria. While the number of reports discussing the underlying mechanisms of Mutaflor has increased rapidly in recent years, novel clinical studies are missing. Escherichia coli Nissle 1917 (Mutaflor) is one of the most extensively studied probiotic bacterium. It was isolated in 1917 by Prof. Nissle from feces from a soldier during the First World War, who did not suffer from diarrhoea as his comrades did. Prof. Nissle realized the potential health benefits early on . AD2Wsk.

mutaflor e coli nissle 1917